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Fluka Chemical ro5-4864
Ro5 4864, supplied by Fluka Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/ro5-4864/ro5+4864/pmc07572456-179-6-10
Average 90 stars, based on 1 article reviews
ro5-4864 - by Bioz Stars, 2026-09
90/100 stars

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Article Title: Peripheral benzodiazepine receptors in androgen sensitive dunning rat prostatic adenocarcinoma.
Article Snippet: Peripheral benzodiazepine receptor (PBZr) binding sites in isolated mitochondrial (m-fractions) and microsomal fractions (p-fractions) from androgen sensitive R-3327 Dunning G and H tumors were studied.. Binding in both mand p-fractions of these tumors was specific, saturable, and of high affinity.. A very high density of PBZr was found in m-fraction from both types of tumors.

Article Title: Effect of the triakontatetraneuropeptide (TTN) on corticosteroid secretion by the frog adrenal gland.
Article Snippet: Ro5-4864 was obtained from Fluka Chimie (St Quentin Fallavier, France).

Article Title: Elevated concentrations of mitochondrial peripheral benzodiazepine receptors in ovarian tumors.
Article Snippet: Us ing PK 11195, a high affinity l igand for peripheral benzodiazepine receptor (PBZr) binding sites in isolated mitochondria (m-fraction) and microsomal fraction (p-fraction) from human ovaries and ovarian tumors were studied.. Binding in both m and p-fractions from ovaries and tumors were saturable and of high affinity.. The PBZr density in mand p-fractions from ovaries was very similar whereas the binding in m-fraction in ovarian tumors was nearly 3-fold higher than p-fraction.

Article Title: Acute chloroquine poisoning: A comprehensive experimental toxicology assessment of the role of diazepam
Article Snippet: MTBE was purchased from Fisons, Loughborough; Ro5‐4864 was purchased from Fluka Chemika, Gillingham, Dorset; Hypnorm (fentanyl/fluanisone) was from Janssen Animal Health, Petteridge, Kent; Amprol Plus (Amprolium HCl/ethopabate) was from Merk Sharp & Dohme, Hertfordshire; and sodium pentobarbitone was from RMB Animal Health Ltd, Dagenham.

Article Title: Translocator protein (18 kDa) mediates the pro-growth effects of diazepam on Ehrlich tumor cells in vivo.
Article Snippet: Diazepam (Cristália do Brasil S/A), Ro5-4864 (4′chloro-diazepam, Fluka), and PK 11195 (1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinoline-carboxamide, Sigma) were diluted in a mixture of propylene glycol and Ringer's solution (20%).

Article Title: Different glial response to methamphetamine- and methylenedioxymethamphetamine-induced neurotoxicity.
Article Snippet: The consequences of the neurotoxic insult induced by 3,4-methylenedioxymethamphetamine (MDMA, an amphetamine derivative with specific action on the serotonergic system) were compared with those of methamphetamine (a derivative with specific action on dopaminergic system) in rats.. Both drugs induced a very similar loss of body weight, especially evident 24 h after treatment.. Their hyperthermic profile was also very similar and was dependent on ambient temperature, corroborating the thermo-dysregulatory effect of both substances.

Article Title: Octadecaneuropeptide ODN prevents hydrogen peroxide-induced oxidative damage of biomolecules in cultured rat astrocytes.
Article Snippet: Oxidative stress, associated with a variety of disorders including neurodegenerative diseases, is a major cause of cellular dysfunction and biomolecule damages which play a crucial role in neuronal apoptosis.. Astrocytes specifically synthesize and release endozepines, a family of regulatory peptides, including the octadecaneuropeptide ODN.. We have recently shown that ODN is a potent glioprotective agent that prevents hydrogen peroxide (H2O2)-induced oxidative stress and apoptosis.



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Subcellular structures detected by TEM. a There existed a large number of mitochondria with the normal structures and the intact cristae in Control group. b Mitochondrial injury was severe in LPS group. c The PBR <t>agonist</t> <t>Ro5-4864</t> alleviated LPS-induced mitochondrial injury. d The PBR antagonist PK 11,195 alleviated LPS-induced mitochondrial injury
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Subcellular structures detected by TEM. a There existed a large number of mitochondria with the normal structures and the intact cristae in Control group. b Mitochondrial injury was severe in LPS group. c The PBR <t>agonist</t> <t>Ro5-4864</t> alleviated LPS-induced mitochondrial injury. d The PBR antagonist PK 11,195 alleviated LPS-induced mitochondrial injury
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Subcellular structures detected by TEM. a There existed a large number of mitochondria with the normal structures and the intact cristae in Control group. b Mitochondrial injury was severe in LPS group. c The PBR <t>agonist</t> <t>Ro5-4864</t> alleviated LPS-induced mitochondrial injury. d The PBR antagonist PK 11,195 alleviated LPS-induced mitochondrial injury
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Subcellular structures detected by TEM. a There existed a large number of mitochondria with the normal structures and the intact cristae in Control group. b Mitochondrial injury was severe in LPS group. c The PBR <t>agonist</t> <t>Ro5-4864</t> alleviated LPS-induced mitochondrial injury. d The PBR antagonist PK 11,195 alleviated LPS-induced mitochondrial injury
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Subcellular structures detected by TEM. a There existed a large number of mitochondria with the normal structures and the intact cristae in Control group. b Mitochondrial injury was severe in LPS group. c The PBR <t>agonist</t> <t>Ro5-4864</t> alleviated LPS-induced mitochondrial injury. d The PBR antagonist PK 11,195 alleviated LPS-induced mitochondrial injury
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Subcellular structures detected by TEM. a There existed a large number of mitochondria with the normal structures and the intact cristae in Control group. b Mitochondrial injury was severe in LPS group. c The PBR <t>agonist</t> <t>Ro5-4864</t> alleviated LPS-induced mitochondrial injury. d The PBR antagonist PK 11,195 alleviated LPS-induced mitochondrial injury
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Subcellular structures detected by TEM. a There existed a large number of mitochondria with the normal structures and the intact cristae in Control group. b Mitochondrial injury was severe in LPS group. c The PBR agonist Ro5-4864 alleviated LPS-induced mitochondrial injury. d The PBR antagonist PK 11,195 alleviated LPS-induced mitochondrial injury

Journal: Journal of Inflammation (London, England)

Article Title: Mitochondria protective and anti-apoptotic effects of peripheral benzodiazepine receptor and its ligands on the treatment of asthma in vitro and vivo

doi: 10.1186/s12950-024-00383-0

Figure Lengend Snippet: Subcellular structures detected by TEM. a There existed a large number of mitochondria with the normal structures and the intact cristae in Control group. b Mitochondrial injury was severe in LPS group. c The PBR agonist Ro5-4864 alleviated LPS-induced mitochondrial injury. d The PBR antagonist PK 11,195 alleviated LPS-induced mitochondrial injury

Article Snippet: Midazolam (Jiangsu Enhua, China), Ro5-4864 (MedChemExpress, USA), PK 11,195 (MedChemExpress, USA) and Cyclosporine-A (MedChemExpress, USA) were diluted in the Keratinocyte Medium containing 0.1% (v/v%) DMSO, achieving final concentrations of 2 μM, 10 μM, 10 μM, and 10 μM, respectively.

Techniques: Control

Inflammatory cells in BALF. Cell smears with Wright-Giemsa staining: The inflammatory cells were increased and aggregated on the BALF smear of OVA group, decreased and scattered after the treatment of the Dexamethasone. Both Ro5-4864 and PK 11,195 made a decrease and scatter of inflammatory cells on the BALF smear in OVA-treated mice. Cell counting: The total numbers of cells (10 6 /ml) in the BALF are presented as mean ± SD. * p = 0.001 < 0.05 vs. Control group. ** p = 0.001 < 0.05 vs. OVA group. Bar = 50 μm

Journal: Journal of Inflammation (London, England)

Article Title: Mitochondria protective and anti-apoptotic effects of peripheral benzodiazepine receptor and its ligands on the treatment of asthma in vitro and vivo

doi: 10.1186/s12950-024-00383-0

Figure Lengend Snippet: Inflammatory cells in BALF. Cell smears with Wright-Giemsa staining: The inflammatory cells were increased and aggregated on the BALF smear of OVA group, decreased and scattered after the treatment of the Dexamethasone. Both Ro5-4864 and PK 11,195 made a decrease and scatter of inflammatory cells on the BALF smear in OVA-treated mice. Cell counting: The total numbers of cells (10 6 /ml) in the BALF are presented as mean ± SD. * p = 0.001 < 0.05 vs. Control group. ** p = 0.001 < 0.05 vs. OVA group. Bar = 50 μm

Article Snippet: Midazolam (Jiangsu Enhua, China), Ro5-4864 (MedChemExpress, USA), PK 11,195 (MedChemExpress, USA) and Cyclosporine-A (MedChemExpress, USA) were diluted in the Keratinocyte Medium containing 0.1% (v/v%) DMSO, achieving final concentrations of 2 μM, 10 μM, 10 μM, and 10 μM, respectively.

Techniques: Staining, Cell Counting, Control

Histopathological examination. The lungs histopathological examination showed the injury of BECs and the infiltration of inflammatory cells in the peribronchial and submucosal tissue spaces in OVA group. The injury of BECs and the infiltration of inflammatory cells were abated after the treatments of Ro5-4864, PK 11,195 and Dexamethasone

Journal: Journal of Inflammation (London, England)

Article Title: Mitochondria protective and anti-apoptotic effects of peripheral benzodiazepine receptor and its ligands on the treatment of asthma in vitro and vivo

doi: 10.1186/s12950-024-00383-0

Figure Lengend Snippet: Histopathological examination. The lungs histopathological examination showed the injury of BECs and the infiltration of inflammatory cells in the peribronchial and submucosal tissue spaces in OVA group. The injury of BECs and the infiltration of inflammatory cells were abated after the treatments of Ro5-4864, PK 11,195 and Dexamethasone

Article Snippet: Midazolam (Jiangsu Enhua, China), Ro5-4864 (MedChemExpress, USA), PK 11,195 (MedChemExpress, USA) and Cyclosporine-A (MedChemExpress, USA) were diluted in the Keratinocyte Medium containing 0.1% (v/v%) DMSO, achieving final concentrations of 2 μM, 10 μM, 10 μM, and 10 μM, respectively.

Techniques: